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Mesoporous silica nanoparticles(MSNs)are a promising material for drug delivery.We delicately prepared a mesoporous silica nanoparticle(MSN)for the delivery of low water solubility drug to tumor cells.In this study,mesoporous silica MCM-41 nanoparticles were used as the core for loading antineoplastic compound ursolic acid(UA).Meanwhile,the ursolic acid(UA)was covalently conjugated to the surface of nanoparticles.