HMGB1 Drove the Pathogenic Th1-like Th17 cells Expansion in Atherosclerosis Patients by Controlling

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:juyexia
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Th17 cells, as a high plasticity subset of T helper cells with proinflammatory actions, were recently identified by the differentiation factors and transcription factors.The flexibility of Th1 7 cells and their shift to IL-17 and IFN-γdoubleproducing Th1 7 (Th1-like Th1 7 cells) phenotype has been linked to the pathogenic Th1 7;which were implicated in autoimmune diseases disorders.However, their properties were only partially known in human;the molecular mechanisms and external factors that govern generation of Th1-like Th17 cells were incomplete clear.
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