【摘 要】
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The lipase catalyzed carbonyl α-substitution reactions such as Michael reaction, aldol reaction and Mannich reaction etc.reported previously were left unsa
【机 构】
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CourseofChemicalandBiologicalEngineering,DivisionofSustainableandEnvironmentalEngineering,MuroranIns
【出 处】
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第六届亚洲特大城市环境与公共健康论坛暨中国环境科学学会环境医学与健康分会2015年会
论文部分内容阅读
The lipase catalyzed carbonyl α-substitution reactions such as Michael reaction, aldol reaction and Mannich reaction etc.reported previously were left unsatisfied in those chemical yield and stereoselectivity.Furthermore, the reports about their application to a domino reaction were very rare.Therefore, in this study,we tried to develop a novel efficient carbonyl α-substitution reaction using lipases.In Michael reaction for the synthesis of warfarin, we found a procedure with good chemical yield and stereoselectivity.Additionally, we tried syntheses of bicyclic compounds by a domino Michael-aldol reaction and gave products in good yields.
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