Objective To investigate the relationship of plasma hs-CRP,IL-6,IL-18 level with acute ischemic stroke severity and clinical outcome.Method The plasma level of hs-CRP,IL-6,IL-18 24h after symptom onset was identified by ELISA method,and then its relationship with stroke severity and clinical outcome was analysed.Results Plasma hs-CRP and IL-6 but IL-18 levels correlated with clinical severity and 3 months outcome.Patients with the highest level of hs-CRP and IL-6 was more likely to develop severe stroke [OR,4.7(2.2-10.2) and 7.5(3.1-18.2),respectively] and had bad outcome [OR,2.5(1.2-5.0) and 2.3(1.1-4.6),respectively].No such results was found with IL-18.Conclusion Plasma hs-CRP and IL-6 levels at acute phase after stroke correlate with stroke severity,and is one of the risk factor for 3 months outcome.