【摘 要】
：
It is very important to obtain uniform molecularly imprinted microspheres (MIMs) for HPLC and SPE applications.Up to now, the most common preparation methods for MIMs include suspension polymerization
【机 构】
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School of Chemistry & Environment, South China Normal University, Guangzhou, 510006, China
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
论文部分内容阅读
It is very important to obtain uniform molecularly imprinted microspheres (MIMs) for HPLC and SPE applications.Up to now, the most common preparation methods for MIMs include suspension polymerization, surface-imprinting polymerization and precipitation polymerization and so on.Among those methods, the precipitation polymerization possesses some advantages of simple operation, without surfactant and stirring, etc.However, it is difficult to obtain big-size (>3 μm) MIMs for HPLC and SPE applications due to the limit of the synthesis method itself.In this study, three anti-human immune-deficiency virus (anti-HIV) drugs commonly used in clinic were utilized as the imprinting templates.The synthesis conditions using precipitation polymerization for achieving uniformed molecularly imprinted microspheres (MIMs) above 3 μm were investigated in detail.
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