【摘 要】
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Metal carbenes derived from transition metal-catalyzed decomposition of diazo compounds react with nucleophiles with heteroatoms,such as alcohols and amines,to
【机 构】
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ShanghaiEngineeringResearchCenterofMolecularTherapeuticsandNewDrugDevelopment,SchoolofChemistryandMo
【出 处】
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第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛
论文部分内容阅读
Metal carbenes derived from transition metal-catalyzed decomposition of diazo compounds react with nucleophiles with heteroatoms,such as alcohols and amines,to generate highly active oxonium/ammonium ylides intermediates.They can undergo traditional 1,2-H shift to form C-X and C-C bonds.We found that these intermediates also can be trapped by appropriate concomitant electrophiles through nucleophilic addition to provide three-component products.Based on this novel trapping process,we have developed various novel multicomponent reactions(MCRs) of diazo compounds,alcohols/anilines,and a number of electrophiles,such as imines,aldehyde,and Michael acceptors.The nucleophiles were extended to electron-rich heterocycles(indoles and pyrroles) and arenes,in which the resulted zwitterionic intermediates were also trapped by electrophiles.
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