Dopamine, a kind of catecholamine neurotransmitter, is indispensable to pain responses.Multiple evidences demonstrated that dopamine D2 receptor (DRD2), gap junction and glia may participate in regula
Gap junctions (G J) play an important role in intercellular communication between adjacent cells.The protein expression, membrane cluster, subtype couple, pore selectivity and gating of GJs might be r
Voltage-gated sodium (Nav) channels play key roles in induction, transmission,transduction of pathological pain.Nay channels are composed of a pore-forming αt subunit and associated β subunits.Each of
Alpha2-adrenergic receptor (alpha2-AR) is involved in the modulation of pain occurrence and development.It reported that alpha2A-AR controlled the conduction and permeability of gap junction channels
Renal tubule interstitial fibrosis is the common and final pathologic change of kidney in end-stage renal disease.Endoplasmic reticulum (ER) stress contributes to the pathophysiological mechanisms dur
Many published studies have indicated that the growing application of complementary and alternative medicine, particularly Traditional Chinese Medicine (TCM) use in combination with conventional cance
Epidemiological studies suggest that an increase of diesel exhaust particles (DEP) in ambient air corresponds to an increase in hospital recorded myocardial infarctions and atherosclerosis after expos
皮肤为阻挡环境物质暴露的主要屏障,可以阻挡许多有害的物质.在评估化合物暴露之伤害时,化合物穿皮能力是重要的考虑因素.过去研究一般利用实验方法测量化合物穿皮能力,然而耗时费力,因此若能开发准确的计算方法预测化合物穿皮能力来初步筛选化合物,再利用实验方法确认化学物质穿透皮肤组织的能力,便能加速化合物暴露风险评估过程并减少实验动物使用,同时也能应用于发展穿皮药物.本研究首先从文献中搜集了197个化合物之
Maternal bacterial infections during pregnancy represent a significant risk factor in neuropsychiatric disorders with a presumed neurodevelopmental failure.The down-streaming syndrome, neuroinflammati
能源危机与环境污染问题近年来广受世界各国所重视,无不积极投入研发替代能源以及减少环境污染排放.而麻疯树籽实含油量(39％)较一般籽类作物高,为深具潜力的生质燃料原料来源,与柴油相较起来,麻疯树油动态黏度(4.2mm2/s)、密度(881 kg/cm2)、十六烷值(48.1)及燃料消耗率(231 g/kW-h)较高,热值(39.6 Mj/kg)、制动热效率则较低,其特性的差异也使引擎的性能发生不同的