【摘 要】
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Background, Motivation and Objective Hepatic steatosis is a common condition, the prevalence of which is increasing along with non-alcoholic fatty liver disease (NAFLD). Currently, the most accurate n
【机 构】
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Institut Langevin, ESPCI ParisTech, PSL Research University, CNRS UMR 7587, INSERM U979, Paris, Fran
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Background, Motivation and Objective Hepatic steatosis is a common condition, the prevalence of which is increasing along with non-alcoholic fatty liver disease (NAFLD). Currently, the most accurate noninvasive imaging method for diagnosing and quantifying hepatic steatosis is MRI, which estimates the Proton-Density Fat Fraction (PDFF) as a measure of fractional fat content (Leporq, 2013). However MRI has several limitations including cost, contra-indications and poor availability that could be overcome by using ultrasound. Although conventional ultrasound is widely used by radiologists for hepatic steatosis assessment, it remains qualitative. It is well known that speed of sound within soft tissues varies slightly with fat content. The objective of this study is to assess the accuracy for steatosis detection and staging of a specific ultrasonic sequence for sound speed estimation (SSE). A preliminary clinical trial was undertaken, with PDFF measurement as a gold standard, to test this new sequence based on the assessment of spatio-temporal properties of the local speckle noise for SSE.
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