The catalytic region and PEST domain of PTPN18 distinctlyregulate the HER2 phosphorylation and ubiqu

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:nmgbmm
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The tyrosine phosphorylation barcode encoded in the HER2 C-terminus and ubiquitinationregulate diverse HER2 functions.PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HER2 signaling is not fully understood.
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