【摘 要】
：
To evaluate the role of the DNA methylation of the CpG island within the PON1 promoter on the clinical efficacy of the dual-antiplatelet therapy of aspirin and clopidogrel in patients with CAD after p
【机 构】
：
Medical Research Center of Guangdong General Hospital,Guangdong Provincial Cardiovascular Institute,
【出 处】
：
中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议
论文部分内容阅读
To evaluate the role of the DNA methylation of the CpG island within the PON1 promoter on the clinical efficacy of the dual-antiplatelet therapy of aspirin and clopidogrel in patients with CAD after percutaneous coronary intervention (PCI).
其他文献
目的:急性髓系白血病(Acute myeloid leukemia,AML)的化疗疗效和预后存在较大的个体差异.WT1基因编码的转录因子具有激活或抑制基因转录的作用,对人体正常造血发挥重要调控作用,该基因位点rs 16754多态性与欧美人群WT1基因表达和AML预后相关.本研究旨在在中国AML患者中查明WT1rs16754多态性对蒽环类联合阿糖胞苷化疗疗效和疾病预后的影响及其机制.
目的:通过检测可能导致DPD功能缺失的编码基因突变及非编码区域的一些基因突变,分析其与5-Fu在消化道肿瘤患者的不良反应发生率的相关性,为消化道肿瘤患者5-Fu的个体化治疗提供依据.方法:收集52例胃肠道肿瘤患者EDTA抗凝静脉血2mL,测序法测定DPD基因的85T＞C、1627A＞G、2194G＞A、464T＞A、496A＞G、2846A＞T、1236G＞A等位点的SNP,评价患者DPD基因SN
Objectives: To build a novel pharmacokinetics (PK) model based on complex drug elimination and disease development for monoclonal antibody (mAb) drugs pharmacokinetics study.
目的:近期研究发现富含脯氨酸跨膜蛋白2基因(PRRT2)与发作性运动诱发性运动障碍(PKD),PKD合并惊厥,PKD合并偏头痛及良性家族性婴儿癫痫(BFIE)相关.本研究旨在探讨PRRT2突变是否与热性发作疾病如高热惊厥附加综合征(FS+),全身性癫痫伴热性惊厥附加综合征(GEF S+)及dravet综合征(DS)相关.
Purpose: Oxysophocarpin (OSC), primarily effective and toxic ingredient that is well-known target markers of radix S.tonkinensis, have been found to have anti-inflammatory, antitumor, and antipyretic
Objective: To investigate the pharmacokinetics and tissue distribution of nuciferine to better understand its behavior and action mechanism in vivo.
Objective: To investigate methological considerations of an HPLC-QTRAP based method for metabonomic analysis and applied it into hyperlipemia.
目的:建立大鼠血浆中京尼平苷快速液相色谱-串联质谱(LC/MS/MS)检测方法.方法:以芍药苷为内标,血浆样品用甲醇沉淀蛋白法处理,色谱柱为Agilent ZORBAX Eclipse plus-C18(2.1×150mm,3.5μm)柱;流动相为甲醇-SmM乙酸铵(含5mM乙酸)(60∶40);采用电喷雾离子化(ESI)和正离子多离子反应监测(MRM)方式检测京尼平苷.
Objective: To filter the genes related to lung cancer by network pharmacology and to discuss the relationship with lung cancer-related genes and influence factors.
康普瑞丁磷酸二钠(简称CA4P)是combretastatin的磷酸二钠盐,是一种靶向抗实体癌的前体药物.CA4P可以选择性地破坏肿瘤相关血管,通过秋水仙碱结合位点和内皮细胞微管蛋白β亚单位结合,导致微管解聚、破坏内皮细胞骨架,从而降低血流,达到阻断血管、靶向治疗的目的.目的:在患有实体肿瘤的病人中进行不同剂量注射用CA4P人体药代动力学研究.