Hepatocellular carcinoma (HCC) typically originates from HBV or HCV associated liver cirrhosis.Primary Sj?gren’s Syndrome (pSS) is a kind of autoimmune disease.A sixty-two year old female patient with mild liver damage was diagnosed with pSS after excluding viral,alcoholic and drug-induced hepatitis according to serum immunological detection and liver biopsy.But when she was hospitalized for a second time two years later,a CT scan revealed liver neoplasm.Surgery confirmed HCC and liver cirrhosis by pathology.The elevated level of AFP recovered to normal after tumorectomy.In conclusion,HCC might be a candidate outcome in patients with pSS; it is the doctors’ responsibility to keep this kind of patient under surveillance.