Graft-versus-host disease causes broad suppression of hematopoietic primitive cells and block in meg

来源 :2014天津国际干细胞论坛 | 被引量 : 0次 | 上传用户：dumala

【摘要】

：

Cytopenia and delayed immune reconstitution with acute graft-versus-host disease (aGvHD) indicate a poor prognosis.However,how donor-derived cell hematopoiesis is impaired in aGvHD is not well underst

【作者】

：

Yan Lin Xiaoxia Hu Hui Cheng Yakun Pang Libing Wang Lin Zou Sheng Xu Xiaomeng Zhuang Chuanhe Jiang Weiping Yuan Tao Cheng Jianmin Wang

【机构】

：

Institute of Hematology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China

【出处】

：

2014天津国际干细胞论坛

【发表日期】

：

2014年3期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Hematopoietic stem cells are silenced in leukemic bone marrow via Egr3

The balance between primitive and mature blood cells is governed by both intrinsic and extrinsic factors.However,this balance can be severely disrupted in disease conditions,such as leukemia.

会议

Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells

Cardiac resident stem cells (CSCs) represent a responsive stem cell reservoir within the adult myocardium and recent studies have revealed that CSCs have a significant function in myocardial hemostasi

会议

Targeting INK4 Protein p18INK4c with Small Molecule Inhibitors for Hematopoietic Stem Cell Expansion

Among cyclin-dependent kinase inhibitors (CKIs) that control the G1 phase in cell cycle,only p18 and p27 can negatively regulate hematopoietic stem cell (HSC) self-renewal.

会议

The antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immun

Immuno-compromised mice,such as the non-obese diabetic/severe combined immune-deficient (NOD/SCID) mice,have been widely used to examine the in vivo self-renewal and differentiation of human hematopoi

会议

Rictor/mTORC2 regulates mouse T-ALL development via FoxO3a

T-cell acute lymphoblastic leukemia (T-ALL) is accounted for about 25％ of adult ALL and 10-15％ of childhood ALL.Hyper-activation of the PI3K/Akt/mTOR pathway sustains Notch1 mutation induced T-ALL via

会议

Influences of chemotherapy on primitive hematopoietic cells and their leukemic companions:studies in

Purpose:To establish a leukemia-therapy model,and study the changes of hematopoietic stem/progenitor cells and their leukemic companions post therapy.

会议

Presence of CD34+CD38-CD58-Leukemia-Propagating Cells at Diagnosis Identifies Patients at High-risk

Aims:Relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) results from the persistence of leukemic stem cells,termed leukemia-propagating cells (LPCs).In Ph+ALL,we recentl

会议

Somatic cell reprogramming by nuclear transfer and defined conditions:which is more appropriate for

Somatic cell reprogramming holds great promise in future clinical applications,especially in the treatment of degeneration disorders caused by aging.Reversion of telomere dysfunction and mitochondrial

会议

Role of rotary suspension culture on differentiation of pluripotent stem cells

Pluripotent stem cells are a potential cell source for cell-therapies with the ability both to self-renew and to differentiate into specialized cells.

会议

Hematopoietic suppression in leukemic marrow is partially mediated by dysfunctional mesenchymal stem

We have previously showed that normal hematopoietic and progenitor stem cells (HSPC) were progressively suppressed during leukemogenesis (Hu et al.,2009),suggesting hematopoietic niche may play a role

会议

Graft-versus-host disease causes broad suppression of hematopoietic primitive cells and block in meg

与本文相关的学术论文