Down-regulating NEP induces endothelial-to-mesenchymal transition via reciprocal regulation of PDGF-

来源 :中国病理生理学会第十届全国代表大会 | 被引量 : 0次 | 上传用户:ljc20090204
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AIM:To verify the mechanism of endothelial-to-mesenchymal transition(EndoMT) involved in pulmonary artery remodeling(PAR),and to investigate whether EndoMT in pulmonary artery hypertension(PAH) could be inhibited.METHODS:The methods of multiple immunofluorescence staining,morphologic analysis,Western blotting and coimmunoprecipitation were applied to identify the role of EndoMT in the PAR and the molecular mechanisms participating EndoMT.
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