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Nanoparticles offer an ideal platform for the development of multimodal probes.Among these,the dopaminemelanincolloidal nanospheres(Dpa-melanin CNSs) are highly superior for such applications.Dpa-melaninCNSs are completely composed of Dpa-melanin that is widely distributed throughout the human body.Thiscan effectively avoid serious adverse effects associated with the long-term retention of foreign substances inpatients.