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As a member of octaketides from marine fungus,not only cytosporone B(Csn-B)is a naturally occurred agonist for Nur77 which may represent a promising therapeutic drug for cancers and hypoglycemia1,but also exhibits a strong inhibitory effect on SPI-1-mediated invasion to HeLa cells2.To study the structure and activity relationship(SAR)and discover more effective agents,eight derivatives of Csn-B and Csn-B(12-20)were synthesized via esterification,deprotection,benzyl protection,Friedel-Crafts reaction,deprotection and interesterification(Scheme 1).