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  5. Clarithromycin ion pair in liposomal membrane to improve its stability and reduce its intravenous ir

Clarithromycin ion pair in liposomal membrane to improve its stability and reduce its intravenous ir

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：zerorolove
【摘 要】
：
To improve the drug loading and stability of clarithromycin (CLA) loaded liposomes, a novel ion pair (IP) approach prior to encapsulation was applied using Cholesteryl hemisuccinate (CHEMS) and confir
【作 者】
：
Yu Zhang Sicong Geng Xing Tang 
【机 构】
：
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
clarithromycin ion pair liposome Cholesteryl hemisuccinate high drug loading les 
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　　To improve the drug loading and stability of clarithromycin (CLA) loaded liposomes, a novel ion pair (IP) approach prior to encapsulation was applied using Cholesteryl hemisuccinate (CHEMS) and confirmed by Fourier transform infrared spectroscopy (FTIR), 1H-NMR, differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD).
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