【摘 要】
：
Psychiatric disorders, particularly in older adults, are often associated with insomnia, early morning awakenings, desynchronization of circadian rhythms and neurochemical dysfunction.Melatonin promot
【机 构】
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Department of Pharmacology,SUNY Buffalo, New York, USA
【出 处】
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2016‘’国际老年健康论坛·泰山
论文部分内容阅读
Psychiatric disorders, particularly in older adults, are often associated with insomnia, early morning awakenings, desynchronization of circadian rhythms and neurochemical dysfunction.Melatonin promote sleep, entrains circadian rhythms, and modulates neurochemical responses through activation of two G-protein coupled melatonin receptors, the MT1 and MT2.This presentation will review the mechanisms involved in the regulation and signaling of the MT1 and MT2 melatonin receptors, and their role as targets for the treatment of mood disorders using novel melatonin ligands, including those currently used in humans (e.g., agomelatine).
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