Path Dependent PDEs (PPDEs, for short) is a convenient tool to characterize the value functions of various types of stochastic control problems in non- Markovian framework. Its typical examples include Backward SDEs (semi- linear PPDEs), second order BSDEs (path dependent HJB equations), path dependent Bellman-Isaacs equations, and Backward Stochastic PDEs. PPDEs can rarely have classical solutions. In this talk we shall propose a notion of viscosity solutions for PPDEs and establish its wellposedness. Our definition relies heavily on the Functional Ito formula initiated by Dupire. Unlike the viscosity theory of standard PDEs, the main difficulty in path dependent case is that the state space is not locally compact. To overcome such difficulty, we replace the pointwise maximization in standard theory with an optimal stopping problem under Pengs nonlinear expectation. The talk will be based on joint works with Nizar Touzi, and Ibrahim Ekren, Christian Keller, Triet Pham.