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Background: The finding of the cancer/testis antigens provides strong evidence for the theory that there exists correlation between development of germ cells and malignant tumorigenesis.Methods: RNF17
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Background: The finding of the cancer/testis antigens provides strong evidence for the theory that there exists correlation between development of germ cells and malignant tumorigenesis.Methods: RNF17 (Ring Finger Protein 17), a cancer/testis antigen is obtained by prostate cancer proteomics and bioinformatics analysis of testis specific genes.And the expression of RNF17 has been verified by WB, IF, PCR in primordial germ cells and sperm stem cells.The tissue arrary analysis of 360 prostate cancer cases showed that the expression of RNF17 had relationship with the clinical parameters.
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