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Claudin-7 (CLDN7),a key integral protein,plays a vital role in integrating to the structure and function of tight junctions by providing the barrier function and permitting selective paracellular transport.We have previously found a severe renal salt wasting in CLDN7 deficient (CLDN7-/-) mice.However,the mechanism of CLDN7 function rich expressed in renal collecting duct (CD) has not yet been well addressed.