Molecular mechanism of the partition of 2-aminoethyldiphenylborinate in a fully hydrated lipid bilay

来源 :第十三届全国量子化学会议 | 被引量 : 0次 | 上传用户：adder2001

【摘要】

：

【作者】

：

Qiang Zhu Yilin Lu Hao Dong Jing Ma

【机构】

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Kuang Yaming Honors School,Nanjing University,210023,P.R.China;Institute of Theoretical and Computat

【出处】

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第十三届全国量子化学会议

【发表日期】

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2017年10期

【关键词】

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2-aminoethyldiphenylborinate partition coefficient free energy entropy molecular

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　　2-Aminoethoxydiphenylborate(2-APB)is a broad-spectrum modulator of various membrane proteins.Specifically,it exhibits concentration dependent modulation of calcium signaling through store-operated calcium(SOC)channels,and the dual functionality of 2-APB for SOC channels is likely associated with its ability to switch among isomeric forms.

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Molecular mechanism of the partition of 2-aminoethyldiphenylborinate in a fully hydrated lipid bilay

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