【摘 要】
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Objective N-methyl-D-aspartate (NMDA) receptor ligands have been shown to rapidly treat depression but are associated with psychotomimetic effects.GLYX-13 (ThrProProThr-amide)is an NMDA receptor glyci
【机 构】
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Department of Psychiatry,Indiana University MedAv
【出 处】
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中华医学会第十一次全国精神医学学术会议暨第三届亚洲神经精神药理学术会议
论文部分内容阅读
Objective N-methyl-D-aspartate (NMDA) receptor ligands have been shown to rapidly treat depression but are associated with psychotomimetic effects.GLYX-13 (ThrProProThr-amide)is an NMDA receptor glycine site functional partial agonist with ～ 25％ of the agonist activity of glycine or D-serine.Animal models suggest a single intravenous dose may produce long-term efficacy without psychotomimetic effects.A phase Ⅱ randomized,double-blind,placebo-controlled trial was conducted to assess the efficacy of GLYX-13 in subjects with inadequate response to previous treatment for major depressive disorder (MDD).This study examines the use of remote blinded independent Central Ratings to assess the efficacy and safety of a putative rapid onset intravenous antidepressant (GLYX-13) with a study design utilizing frequently repeated psychiatric assessments.
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