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Division of Hematology, Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy The clinical course of chronic lymphocytic leukemia (CLL) is extremely heterogeneous.Understanding CLL genetics may help clarify the molecular bases of the clinical heterogeneity of this leukemia.In 2000, this notion was unequivocally documented by D(o)hner et al.who established interphase FISH analysis as a standard technique to evaluate cytogenetic lesions in CLL.Cytogenetic lesions, however, do not entirely explain the genetic basis of the clinical heterogeneity of CLL.