Objective To investigate the synergetic effects of panax notoginseng saponins (PNS) and ginkgetin on Proinflammatory cytokines in Rats with Hyperlipidemia, and explore the clinical significance.Method 24 wistar rats were randomly divided into two groups: the control group(8) fed with standard laboratory chow and the high-fat diet group(16) fed with high-lard/cholesterol diet (83%standard laboratory chow, 2% cholesterol, 10% lard and 5% powder of vitellus).8 weeks later, the high-fat diet group was further divided into two groups: the hyperlipidemic group(8) and the drug-treated group(8).The drug-treated group was administered with panax notoginseng saponins (100mg/kg.d) and ginkgetin (48mg/kg.d) for another two months.At the end of the treatment, The ratio of liver weight/body weight and testicular fat weight/body weight were measured, and the change of plasma proinflammatory cytokine such as IL-6、 TNF-α、 hs-CPR were determined.Results In hyperlipidemic group, the ratio of liver weight/body weight and testicular fat weight/body weight were significantly higher than control group (P<0.01) , and the plasma proinflammatory cytokine level of IL-6、 TNF-α、 hs-CPR were elevated (P<0.01).but these parameters were dramatically decreased in drug-treated group as compared with hyperlipidemic group (p<0.05).Conclusions PNS and ginkgetin have synergetic functions to effectively improve lipid metabolism, and have significant anti-inflammatory effects.