【摘 要】
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The number and subtype composition of N-methyl-d-aspartate receptors(NMDARs)at synapses determines their functional properties and role inlearning and memory.Geneticallyincreased or decreased amount o
【机 构】
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Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,Institutes ofBrain Scienc
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
The number and subtype composition of N-methyl-d-aspartate receptors(NMDARs)at synapses determines their functional properties and role inlearning and memory.Geneticallyincreased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain.But in some experimental conditions,for example,memory elicited by a single CSUS pairing,GluN2B is not a necessary factor,which indicates that the precise role of GluN2B in memory formation requires further exploration.Here,we examined the role of GluN2B in the consolidation of fear memory using two training paradigms.We found that GluN2B was only required for the consolidation of memory elicited by five CS-US,not by a single CS-US pairing.Strikingly,the expressionof membrane GluN2B in CA1wastraining-strength-dependently increasedafterconditioning,and that the amount of membrane GluN2B determined its involvement in memory consolidation.Additionally,we demonstrated that increases in the activities of cAMP,ERK,and CREB were observed in the CA1 region after conditioning,as well as enhanced intrinsic excitabilityand synaptic efficacy in CA1 neurons.Up-regulation of membrane GluN2B contributed to these enhancements.These studies uncover a novel mechanism for the involvement of GluN2B in memory consolidation by its accumulation at the cell surface in response to behavioral training.
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