【摘 要】
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Objective To explore the correlation of aspirin resistance(AR)and recurrent vascular events in patients with acute cerebral infarction.Methods One-hundred and ten patients(mean age 64.7±12.1,64 male a
【机 构】
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Department of Neurology,Peking University Shenzhen Hospital,Shenzhen 518036,China
【出 处】
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广东省医师协会第五届神经内科医师大会
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Objective To explore the correlation of aspirin resistance(AR)and recurrent vascular events in patients with acute cerebral infarction.Methods One-hundred and ten patients(mean age 64.7±12.1,64 male and 56 female)with acute cerebral infarction were consecutively selected who were admitted to the department of neurology in Peking University Shenzhen hospital.Aspirin was administrated regularly to every patient from the first day of admission.Whole blood samples were collected for platelet aggregation testing after aspirin had been administered for 7~10days.AR was detected by whole blood electrical impedance aggregometry(WBA).The impedance induced by 0.5 mmol/l arachidonic acid(AA)>0Ω was identified as AR.The patients were divided into AR group and AS group according to their platelet aggregation.A follow-up period of 6 months was performed to record vascular events,including cerebral infarction,transit ischemic attack(TIA),myocardial infarction and death.Results AR was detected in 31 patients and the prevalence of AR was 28.2%.The proportion of type 2 diabetes mellitus in AR group was higher than that in AS group(P<0.05).Recurrence rate of ischemic vascular events in AR group was higher than that in AS group(22.6%vs 7.9%,P<0.05).Multiple logistic regression analysis found that AR was an independent risk factors for recurrent ischemic vascular events in patients with acute cerebral infarction(OR=4.091,95%CI=0.024~0.946,P<0.05).Conclusion Aspirin resistance is not uncommon in patients with ischemic stroke taking aspirin.Type 2 diabetes mellitus is one of the risk factors for aspirin resistance.Patients who are detected to be AR are at a greater risk of recurrent ischemic vascular events.
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