【摘 要】
：
Traditional literature and textbooks generally describe that testosterone (T) is the main substrate for the biosynthesis of estradiol (E2), the most potent natural estrogen and dihydrotestosterone (DH
【机 构】
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Laval University Canada
【出 处】
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2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
Traditional literature and textbooks generally describe that testosterone (T) is the main substrate for the biosynthesis of estradiol (E2), the most potent natural estrogen and dihydrotestosterone (DHT), the most potent natural androgen.These pathways imply that the steps of aromatization and 5α-reduction follow the reaction of the androgenic17β-hydroxysteroid dehydrogenase (17β-HSD) that catalyzes the conversion of4-androstenedione (4-dione) into T, and that estrogenic 17β-HSDs are not required (4-dione-17β-HSD →3e T---aromatase →3e E2, and 4-dione-17β-HSD →3e T---5α-reductase →3e DHT).On the other hand, the observation that 4-dione possesses higher affinity for aromatase and 5α-reductase than T and the cloning of many estrogen-specific 17β-HSDs strongly suggest that the pathways of DHT and E2 biosynthesis as described by traditional literature that are not thermodynamically relevant should be revised.
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