Chemically microstmctured surfaces have gained increasing attention in the cell biological/ biomaterial community in the past few years.Patterning of biomolecules on solid substrates can be used not only to control cell adhesion and growth but also to regulate cell function.Among the numerous methods to pattern biomolecules on a solid surface,microcontact printing (μCP) is becoming increasingly popular.Microcontact printing has been used to pattern proteins,peptides,direct cellular adhesion,and deposit polymers.This method is particularly suited for evaluating cellular based systems; cell body dimensions are typically tens of microns,the same scale required to study cell motility and interactions.While other systems take advantage of physical barriers to direct cell attachment and growth by creating grooves in the surface,microcontact printing essentially uses only chemical cues to direct cells.Microcontact printing was first used to stamp proteins and peptides on a variety of different surfaces and then the protein or peptide modified surfaces were used to produce pattems of cells for different applications.