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FGF13 is known to be a non-secretory protein of the fibroblast growth factor(FGF)family which is enriched in brain during development and is correlated with two kinds of non-systematically X-linked mental retardation,suggesting its important roles in mental development of human.Previous studies have shown that FGF13B,one of FGF13 isoforms,is a regulator for microtubule assembly during axonal outgrowth and migration of immature neuron.