【摘 要】
：
Chronic inflammation primarily contributes to the abdominal aortic aneurysm (AAA).The nuclear factor (NF)-κB regulated the inflammation.We hypothesized that zinc induces zinc finger protein A20 in vas
【机 构】
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Department of Tissue Engineering, College of Basic Medical Sciences, China Medical University, Sheny
【出 处】
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The 18th Congress of the International Federation of Associa
论文部分内容阅读
Chronic inflammation primarily contributes to the abdominal aortic aneurysm (AAA).The nuclear factor (NF)-κB regulated the inflammation.We hypothesized that zinc induces zinc finger protein A20 in vascular smooth muscle cells (VSMCs) and A20 binds to tumor necrosis factor (TNF)-receptor associated factor, then suppresses activity of NF-κB.AAA was induced by 0.5M CaCl2.Zinc sulfate (ZS)group were administrated with 6 mg/kg/day intraperitoneal ZS for 4 weeks.The abdominal aortic segments were collected at 4 weeks after surgery.We also conducted liposome-mediated gene delivery in primarv rat VSMCs.
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