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Objectives: To evaluate the functional efficacy of a custom-made prosthesis on diaphysis reconstruction after surgical resection of diaphyseal malignant tumors and analyze the usefulness of this method.Methods: We retrospectively reviewed ten patients between 2007 and 2013 who underwent diaphyseal resections and reconstruction with a custom-made prosthetic system for diaphyseal tumors with a mean follow-up of 25.6 (range, 10~46) months.Five patients underwent femoral diaphyseal resections, three underwent humeral diaphyseal resections and two underwent tibialdiaphyseal resections.