The inhibitory effect of Sildenafil on hypoxia induced TRPC expression in pulmonary arterial smooth

来源 :中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户：a2009090720

【摘要】

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【作者】

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Jian Wang Wenju Lu Kai Yang Lei Xu Yi Zhang Ning Lai Hua Jiang Yajie Zhang Nanshan Zhong Pixin Ran

【机构】

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Division of Pulmonary & Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21

【出处】

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中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议

【发表日期】

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2013年2期

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Rationale Transient receptor potential canonical (TRPC) proteins play important roles in chronically hypoxic pulmonary hypertension (CHPH).Previous results indicated sildenafil inhibited TRPC1 and TRPC6 expression in rat distal pulmonary arteries (PA);however, the underlying mechanisms are unknown.

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The inhibitory effect of Sildenafil on hypoxia induced TRPC expression in pulmonary arterial smooth

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