Objective: In order to explore the potential association between the leptin receptor (LEPR) gene polymorphisms and essential hypertension (EH) risk in the Northern Han Chinese population.Methods: We recruited 823 hypertensive subjects and 491 healthy control subjects from the Northern Han Chinese.Genotyping was performed to identify the Lys109Arg, Gln223Arg and Lys656Asn polymorphisms of the LEPR gene.Results: Significant associations were found in a dominant genetic model ([GG+AG] vs AA), P=0.007, odds ratio (OR) =3.697, 95% confidence interval (CI) 1.442-9.482), and in homozygote comparison (GG vs AA, P=0.005, OR=3.890, 95% CI 1.501-10.077) for the Gln223Arg polymorphism.No significant association could be found between Lys109Arg or Lys656Asn polymorphism and EH risk.Linkage disequilibrium was detected between the Lys109Arg and Gln223Arg polymorphisms, and haplotype analyses identified that the G-A haplotype was a protective haplotype for EH.Conclusions: Our studies demonstrated that the LEPR Gln223Arg polymorphism had an important role in a patients susceptibility to EH in the Northern Han Chinese population.