Apocynin,a potent inhibitor of NADPH-oxidase,was widely studied for activities in diseases such as inflammation-mediated disorders,asthma and cardiovascular diseases.
Near-infrared fluorescent dyes have widely used as fluorescence probes,due to their maximum absorption peak is greater than 700nm where a biological matrix exhibits the least absorption and autofluore
The Ras/Raf/MEK/ERK pathway(ERK pathway)is a member of the four distinct mitogen-activated protein kinase(MAPK)signaling pathways,which play critical roles in regulation of diverse cellular activities
Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs [1].Recently,in our laboratory work,maleopimaric N-naphthylimide was found exhibited anti-proliferative act
1,2-benzothiazine derivatives as novel potent anticancer drugs atracted great attention.Several authors have reported their inhibitory effects on colorectal cancer,non-small-cell lung cancer,and osteo
In recent years,the development of EGFR inhibitors focuses on ATP competitive inhibitors,and many small molecules including Gefitinib,Erlotinib and Canertinib etc were approve.