Tea Polyphenol (-)-epigallocatechin-3-gallate Inhibits Nicotine-and Estrogen-induced α9-nicotinic Ac

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户：wangke777

【摘要】

：

【作者】

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Yuan-Soon Ho

【机构】

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Translational Cancer Research Center Graduate Institute of Biomedical Technology Taipei Medical Univ

【出处】

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2011第四届世界癌症大会

【发表日期】

：

2011年3期

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　　The aim of this research was to explore whether the tea-polyphenol (-)-epigallocatechin-3-gallate (EGCG) could be used as an agent for blocking smoking (nicotine, Nic)-or hormone (estradiol, E2)-induced breast cancer cell proliferation by inhibiting a common signaling pathway.We found that Nic (>0.1 μM, 24 h) and E2 (>1 nM, 24 h) significantly increased α9-nicotinic acetylcholine (α9-nAChR) rnRNA and protein expression levels in human breast cancer (MCF7) cells.

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Tea Polyphenol (-)-epigallocatechin-3-gallate Inhibits Nicotine-and Estrogen-induced α9-nicotinic Ac

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