Aim: Cyclic adenosine monophosphate (cAMP)/proteinkinase A (PKA)/cAMP response element binding protein (CREB) signaling cascade negatively regulates PDGF-BB induced smooth muscle cell (SMC) proliferation, which is a critical event in the initiation and development of restenosis and atherosclerotic lesions.DL0707 is one of the polyphenols extracted from salvia.