论文部分内容阅读
Objective To visualize the permeability changes in the blood-inner ear barriers of guinea pigs with acute mitochondria dysfunction and in patients with acute hearing loss using contrast agent-enhanced MRI.Materials and methods An animal model of acute mitochondria dysfunction-induced hearing loss was created by introducing 3-nitropropionic acid (3-NP) intratympanically in guinea pigs.Vestibular disorder and hearing loss were evaluated.An MRI was performed at 2 h after either intravenous (Ⅳ) or intratympanic administration of dimeglumine gadopentetate (Gd-DTPA),using 3D fast-recovery fast spin-echo (FRFSE) and 3D fluid-attenuated inversion recovery (FLAIR) sequences.