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Fibroblast growth factor (FGF) 7, which is also known as keratinocyte growth factor (KGF), is a member of the FGF family.Previous studies regard it as a locally acting epithelial mitogen that is produced by cells of mesenchymal origin and has an important role in protecting and repairing epithelial tissues.However, its potential functions in the nervous system are poorly understood.We found that FGF7, together with its high-affinity receptor FGFR2b, was expressed in both dorsal root ganglion (DRG) and spinal cord neurons.FGF7 mRNA was consistently increased in DRGs after peripheral nerve injury and transiently up-regulated after intraplantar injection of complete Freunds adjuvant.Intrathecal injection of recombinant human FGF7 exacerbated the formalin-induced hyperalgesia, while application with either the antibodies against FGF7 or recombinant FGF R2β (Ⅲb) Fc chimera alleviated inflammatory nociceptive response.Moreover, behavior tests and wide-dynamic range neuron recordings of FGF7 knockout mice showed a defect in nociceptive sensation.Taken together, these results suggest that FGF7 may contribute to inflammatory pain sensation and play an important role in nociceptive transmission.