Background To evaluate the effect of renal insufficiency on short and long term death and major adverse cardiac event(MACE) in octogenarian patients undergoing percutaneous coronary intervention (PCI).Methods A total of 90 patients aged 80 years old and over with coronary heart disease (CAD) undergoing stenting were enrolled in this study.The in-hospital and 2 years clinical follow-up outcome including all-cause mortality, MACE,stroke and other major bleeding were collected and analyzed.Based on estimated glomerular filtration rate level, patientswere divided into two groups: estimated glomerular filtration rate ＜60 ml/min (moderate to severe renal insufficiency group; n=28) and estimated glomerular filtration rate ≥60 ml/min (normal/minimal renal insufficiency group; n=62).