We report a case of unequivocal lifespan extension induced by social interaction rev-ealed inshort-lived SOD1 mutants，defective in cytosolic CuZnSOD enzyme. When co-ho-used with flies ofother genotypes，Sod flies gained an almost 100％ lifespan increas-e,as well as significant enhancement in motor ability and stress resistance. This un-expected finding might provide an entrypoint for identifying the network of the soc-ial interaction-responsive genes.