【摘 要】
：
Lyotropic liquid crystalline phases are currently arousing increasing concern due to their strong capabilities to protect hydrophilic, lipophilic and amphiphilic molecules from hydrolysis and oxidatio
【机 构】
：
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
【出 处】
：
第二届全国生物颗粒学术研讨会、第三届国际工业药学和临床药学研讨会暨第一届岭南国际药学大会
论文部分内容阅读
Lyotropic liquid crystalline phases are currently arousing increasing concern due to their strong capabilities to protect hydrophilic, lipophilic and amphiphilic molecules from hydrolysis and oxidation.Recently, the topical treatment of chronic wounds, such as venous,diabetic and pressure ulcers have become a major clinical challenge.The purpose of this study was to develop recombinant human epidermal growth factor (rhEGF) loaded liquid crystalline precursor for the effective treatment of chronic wounds.Liquid crystalline precursor composed of glycerol monooleate (GMO), ethanol (EtOH) and water was developed and characterized by polarized fight microscopy, small angle X-ray scattering (SAXS).The optimized formulation (GMO/EtOH/water, 72∶ 18∶ 10, w/w/w) loaded with rhEGF showed a strong ability to form a cubic liquid crystalline gel in situ with small amounts of water absorption in the extremely short time.The developed formulation was found to be able to sustain the drug release for more than 10 days and was suitable for topical administration for the treatment of chronic wounds.
其他文献
Synthetic amphiphilic polymers based micelles have been extensively applied for site-specific delivery of bioactive therapeutic and imaging agents.Despite the wide pre-/clinical studies of polymeric m
Active tumor targeting drug delivery is a tumor treatment strategy that improves tumor-cell-specific uptake of drug molecules with enhanced therapeutic efficacy.This strategy entails specific recognit
Currently, there exist six main kinds of drugdelivery systems for peptide drugs: Intravenous, oral,intranasal, transdermal, ocular and pulmonary.Amongst them, pulmonary drug delivery system (PDDS) is
This presentation summarizes the authors experience in the preparation for the development of generic products aiming for the US market.Preparation in literature, API, reference product, excipients, a
Generally speaking, linear conpolymers whose stability increased accompany with the adding of molecular weight, has hindered further adhibition of polymeric micelles due to poor ability in the field o
As a promising new solid form, cocrystal has been increasingly drawn more attention to improve pharmaceutical properties of active pharmaceutical ingredients (API) including solubility, dissolution ro
Combined delivery of drug and gene has emerged as an exciting method of treating cancer which possesses a synergistic effect of increasing drug efficacy or enhancing gene transfection efficiency, ther
Background Docetaxel (DTX), a potent anticancer drug, limited in clinical usage by strong toxicity and side effect, was integrated with a submicron emulsion drug delivery system to enhanced anticancer
Purpose Currently the difficulty in the development of drug-loaded microspheres is the preparation technology, which are not suitable for industrialization due to their intermittent operation and diff
Acid resistant shell-matrix microcapsules, loaded with Streptococcus thermophilus,were prepared by embedding trehalose in the matrix of chitosan-alginate microcapsules.The obtained chitosan-trehalose-