Antimicrobial activity of extract and solvent-solvent partition fractions from the leaves of Tagetes erecta was investigated.The air-dried powdered leaves of T.erecta were extracted with methanol.The residue was redissolved in water which was then subjected to solvent-solvent partition with four organic solvents: hexane, dichloromethane, ethyl acetate and n-butanol.Each of these extracts was tested for their antimicrobial activity against bacteria and yeast strains by disc diffusion method.The results revealed that hexane and methanol extracts showed antimicrobial activity against most of the tested microbes.These two extracts showed inhibition zones against strains of Bordetella pertussis, Methicillin Resistance Staphyloccocus aureus (MRSA), and Vancomycin Resistance S.aureus (VRSA).However, no antifungal activity observed against tested strains of yeasts.Extracts showed a moderate average zone of inhibition ranged from 8.00-14.00 mm.The MIC and MBC values of selected bacterial strains tested ranged from 2.5-10 mg/mL and 5-10 mg/mL.Thus, the hexane fraction was fractionated by column chromatography to obtain 6 fractions (F1 to F6) based on thin-layer chromatography band-pattern similarities.Each fraction was tested for their antimicrobial activity against bacteria strains.The results indicated that fractions F4 and F5 exhibited the greatest activity among the fractions.Further work is needed to isolate and elucidate the active compounds produced by this plant.