【摘 要】
：
Enterovirus 71 (EV71) is a non-enveloped virus and possesses a single-stranded positive RNA genome,which contains a single ORF flanked by a 5untranslated region (5UTR) and a polyadenylated 3UTR.In thi
【机 构】
：
State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan,China
【出 处】
：
第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
论文部分内容阅读
Enterovirus 71 (EV71) is a non-enveloped virus and possesses a single-stranded positive RNA genome,which contains a single ORF flanked by a 5untranslated region (5UTR) and a polyadenylated 3UTR.In this study,we initially demonstrated that EV71 infection activates the production of silent mating type information regulation 2 homolog 1 (SIRT1),a deacetylase,facilitates the sumoylation of SIRT1,stimulates the deacetylase activity of SIRT1,whereas represses the nucleus translocation of SIRT1.
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