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  5. Protective effect of inositol pyrophosphates inhibition against myocardial ischemia reperfusion inju

Protective effect of inositol pyrophosphates inhibition against myocardial ischemia reperfusion inju

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：johnathan126
【摘 要】
：
Background Ischemia/reperfusion (I/R) injury remains the major cause of cardiomyocytes loss and cardiac dysfunction.Akt,a serine/threonine kinase which mediates survival signal through the phosphoryla
【作 者】
：
ZHANG Zheng QIN Xing LI Shuang CAO Feng WANG Hai-chang 
【机 构】
：
Department of Cardiology,Xijing Hospital
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Ischemia/reperfusion (I/R) injury remains the major cause of cardiomyocytes loss and cardiac dysfunction.Akt,a serine/threonine kinase which mediates survival signal through the phosphorylation, exerts a powerful cardioprotective effect.However, the phosphorylation of Akt is down-regulated in isehemia hearts, which aggravates I/R injury.The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is formed by inositol hexakisphosphate kinases (IP6Ks) is a physiologic inhibitor of Akt.This study was designed to investigate the role of IP7 in L/R injury and to test the hypothesis that down-regulating IP7 generation protects against L/R injury.
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