【摘 要】
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Objective The quadratic inference function (QIF) method becomes more acceptable for correlated data because of its advantages over generalized estimating equations (GEE).This study aimed to evaluate t
【机 构】
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Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical Universit
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Objective The quadratic inference function (QIF) method becomes more acceptable for correlated data because of its advantages over generalized estimating equations (GEE).This study aimed to evaluate the relationship between platelet indices and blood pressure using QIF method, which has not been studied extensively in real data settings.Methods A population based longitudinal study was conducted in Beijing from 2007 to 2012, and the median of follow-up was 6-years.A total of 6515 cases, who were aged between 20-65 years at baseline and underwent routine physical examinations every year from three Beijing hospitals, were enrolled to explore the association between platelet indices and blood pressure by QIF method.The original continuous platelet indices were categorized into 4 levels (Q1-Q4) using the 3 quartiles of P25, P50 and P75 as a critical value.GEE was preformed to make a comparison with QIF.Results After adjusting for age, usage of drugs and other confounding factors, mean platelet volume was negatively associated with diastolic blood pressure (DBP) (Q4:(β)/95% CI, P value;-0.7649/-1.1313 to-0.3985, 0.00004) in males and positively linked with systolic blood pressure (SBP) (Q4: (β)/95% CI, P value;3.1926/2.0853 to 4.2999, 0.00001 in female;1.8477/1.3148 to 2.3806, 0.00001 for male).Platelet distribution width was negatively associated with SBP (Q4: (β)/95% CI, P value;-1.5926/-2.5921 to-0.5931, 0.00179 for female;-1.0568/-1.5335 to-0.5801, 0.00001for male).Blood platelet count was associated with DBP (Q4: (β)/95% CI, P value;0.4212/0.0200 to 0.8223, 0.03958) in males.Conclusion Adults in Beijing with prolonged exposure to extreme value of platelet indices have elevated risk for future hypertension and evidences in support of using some platelet indices for early diagnosis of hypertension were provided.
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