2-甲氧雌二醇通过miR-223/IGF-1R/Parp1信号通路改善间歇低氧导致的肺动脉高压

来源 :中国睡眠研究会第十届全国学术年会 | 被引量 : 0次 | 上传用户：yangwenping666

【摘要】

：

肺高血压(PH)在阻塞性睡眠呼吸暂停综合征(OSA)患者中发病率较高,并且PH 和OSA 共患病意味着患者更差的预后和更高的死亡率.然而,PH与OSA 之间的仍不清楚,并且缺乏对于疾病的治疗药物.慢性间歇性低氧(CIH)是OSA 的关键发病机制,导致氧化应激增加和炎症发生.2-甲氧基雌二醇(2-Me)是一种雌二醇代谢物,具有抗增殖特性,并已在PH 模型中进行了探索.因此,我们探究了2-Me 是否以

【作者】

：

郝晟瑜符翠萍李善群

【机构】

：

复旦大学附属中山医院

【出处】

：

中国睡眠研究会第十届全国学术年会

【发表日期】

：

2018年9期

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2-甲氧雌二醇通过miR-223/IGF-1R/Parp1信号通路改善间歇低氧导致的肺动脉高压

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