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Objective: To explore the effects of chronic alcoholism and its withdrawal on the pain timed dose-response relationship(TRDD)in rats.Methods: Sixteen male SD rats were randomly divided into 2 groups,normal group(n=8)and alcohol group(n=8).Rats in alcohol group were fed with alcohol solution as the only water source,which concentration was increased from 6%to 12%at 3%per 2 days,and then 12%alcohol concentration were maintained for 8 weeks.