【摘 要】
：
The furan-containing compounds widely exist in food, herb, synthetic drugs and air pollution, and many of them are toxic.It was proposed that metabolic activation of furan ring was related to their in
【机 构】
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Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
【出 处】
：
2015年第一届药代动力学朝阳论坛
论文部分内容阅读
The furan-containing compounds widely exist in food, herb, synthetic drugs and air pollution, and many of them are toxic.It was proposed that metabolic activation of furan ring was related to their induced toxicity.In the present study, 13 furan-containing compounds, belonging to six structural classes (furan, 2-substituted, 3-substituted, 2, 3-substituted, 2, 5-substituted and 2,3,4,5-substituted furans), were incubated with trapping reagents N-(tert-butoxycarbonyl)-L-lysine (BocLys) with nucleophilic amino group and N-acetvl cysteine (NAC) with nucleophilic thiol group) in NADPH-supplemented human liver microsomes (HLM).
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