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Protein arginine methyltransferaseas (PRMTs) are highly conserved and regulate stability, localization and activity of proteins.We have characterized deletion strains corresponding to genes encoding for PRMT1/3/5 (designated amt-1, amt-3 and skb-1, respectively) in Neurospora crassa.Deletion of PRMT-encoding genes conferred reduced growth rates and altered Arg-methytated protein profiles.△amt-1 exhibited reduced hyphal elongation rates and increased susceptibility to voriconazole.