Activities change of cytochrome P450 and UDP-glucuronyltransferase enzymes in db/db mice

来源 :2015第11届全国药物和化学异物代谢学术会议 | 被引量 : 0次 | 上传用户:cctime
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The db/db mice were a strain of mutant line from C57BL/6J mice, and it is always used as a human type 2 diabetes mellitus animal model.
其他文献
Dauricine is a bisbenzylisoquinoline alkaloid derivative and has shown multiple pharmacological properties.Despite this,our previous study demonstrated that dauricine induced severe lung toxicity in e
Methyleugenol (ME), an alkenylbenzene compound, is a constituent of many foods and is used as flavoring agent in foodstuffs and as fragrance in cosmetics.
会议
Furanoid 8-epidiosbulbin E acetate (EEA) is a major constituent of herbal medicine Dioscorea bulbifera L.(DB), a traditional Chinese medicine herb.
会议
Diosbulbin B (DIOB), a furanoid, is a major constituent of herbal medicine Dioscorea bulbifera L.Exposure to DIOB caused liver injury in humans and experimental animals.
It is still uncertain whether the accumulation of the Bas in hepatocytes beyond the normal stand after taking medicine which can cause hepatic injury or under the pathological state.
考察茵栀黄复方中抗胆汁淤积的主要药效成分,从胆汁酸代谢/炎症通路角度探讨其抗胆汁淤积性肝损伤作用的新机制。选用雄性健康129S/V小鼠,分成正常对照组、ANIT诱导模型对照组、绿原酸组、栀子苷组、黄芩苷组、滨蒿内酯组,采用液相色谱-质谱多反应监测技术开展茵栀黄复方注射液多组分血浆药动学轮廓分析和系统暴露测量;同时检测肝功能、肝组织病理学变化、胆汁酸代谢相关基因和炎症相关基因的mRNA表达及炎症相关
A rapid and simple background-free high-performance liquid chromatography/ electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS) approach has been developed for simultaneously determining
会议
采用放射性标记的方法:研究生物大分子多糖MP-1关节腔内药动学.以14C标记葡萄糖与普通葡萄糖作为混合碳源,通过发酵对MP-1进行放射性标记.给予大鼠关节腔注射0.25、0.5、1 mg/只3个剂量的14C标记MP-1,测定给药后不同时间关节腔内放射性残留.结果:显示通过发酵可成功制备比活度为7.27 μ Ci/mg,放化纯度为99.5%的放射性标记MP-1样品.关节腔注射MP-1 1 mg/只,
目的:对枸橼酸莫沙必利注射液进行临床前药代动力学评价.方法::建立液相色谱-串联质谱(LC-MS/MS)法同时测定比格犬/大鼠血浆及组织中莫沙必利及两种代谢产物,并考察静脉注射给药相对于口服对莫沙必利体内过程的影响.样品经乙酸乙酯萃取后,以Eclipse Plus C18色谱柱分离,以甲醇-0.5%冰乙酸溶液为流动相.采用电喷雾离子源,多重反应监测模式对目标物离子监测.
Tolvaptan is an orally active vasopressin V2 receptor antagonist clinically used in the treatment of hyponatremia.Recently, U.S.FDA issued a black box warning for tolvaptan due to its high risk of liv